Effects of Individual and Built Environmental Features on Commuting Mode Shifts before and after the COVID-19 Outbreak in Guangzhou, China

The novel coronavirus disease (COVID-19) pandemic has had a significant impact on transportation. Understanding how the epidemic in China has affected people's travel mode choices can help city managers analyze the travel mode of different populations in the postepidemic phase. Based on a travel behavior questionnaire conducted in Guangzhou, China, during the COVID-19 epidemic and points-of-interest data, this study explored the impact of the built environment, travel characteristics, and socioeconomic factors on changes in commuters' travel modes during the postepidemic phase. We found that gender, age, occupation, the decline in the rate of travel frequency, and built environment characteristics significantly influenced the change in travel mode. When respondents had to give up public transport, those in different professions had different options for alternative means of transportation. The density of residential facilities, bus stations, and government institutions had a more significant impact on the change in the travel mode of commuters. The research results provide a theoretical basis for policy and practice. After the outbreak of a major public health event, urban transport managers and policymakers should consider individual heterogeneity and environmental factors when formulating strategies to address public travel in unconventional situations. [ FROM AUTHOR] Copyright of Journal of Advanced Transportation is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Supercoiling Structure-Based Design of a Trimeric Coiled-Coil Peptide with High Potency against HIV-1 and Human ß-Coronavirus Infection.

Hexameric structure formation through packing of three C-terminal helices and an N-terminal trimeric coiled-coil core has been proposed as a general mechanism of class I enveloped virus entry. In this process, the C-terminal helical repeat (HR2) region of viral membrane fusion proteins becomes transiently exposed and accessible to N-terminal helical repeat (HR1) trimer-based fusion inhibitors. Herein, we describe a mimetic of the HIV-1 gp41 HR1 trimer, N3G, as a promising therapeutic against HIV-1 infection. Surprisingly, we found that in addition to protection against HIV-1 infection, N3G was also highly effective in inhibiting infection of human ß-coronaviruses, including MERS-CoV, HCoV-OC43, and SARS-CoV-2, possibly by binding the HR2 region in the spike protein of ß-coronaviruses to block their hexameric structure formation. These studies demonstrate the potential utility of anti-HIV-1 HR1 peptides in inhibiting human ß-coronavirus infection. Moreover, this strategy could be extended to the design of broad-spectrum antivirals based on the supercoiling structure of peptides.